Sequential Experimentation in Clinical Trials : Design and Analysis (9781489995988)

Sequential Experimentation in Clinical Trials: Design and Analysis is developed from decades of work in research groups, statistical pedagogy, and workshop participation. Different parts of the book can be used for short courses on clinical trials, translational medical research, and sequential experimentation. The authors have successfully used the book to teach innovative clinical trial designs and statistical methods for Statistics Ph.D. students at Stanford University. There are additional online supplements for the book that include chapter-specific exercises and information.

Sequential Experimentation in Clinical Trials: Design and Analysis covers the much broader subject of sequential experimentation that includes group sequential and adaptive designs of Phase II and III clinical trials, which have attracted much attention in the past three decades. In particular, the broad scope of design and analysis problems in sequential experimentation clearly requires a wide range of statistical methods and models from nonlinear regression analysis, experimental design, dynamic programming, survival analysis, resampling, and likelihood and Bayesian inference. The background material in these building blocks is summarized in Chapter 2 and Chapter 3 and certain sections in Chapter 6 and Chapter 7. Besides group sequential tests and adaptive designs, the book also introduces sequential change-point detection methods in Chapter 5 in connection with pharmacovigilance and public health surveillance. Together with dynamic programming and approximate dynamic programming in Chapter 3, the book therefore covers all basic topics for a graduate course in sequential analysis designs.

Product details

• Format Paperback | 240 pages
• Dimensions 155 x 235 x 13.72mm | 3,927g
• Publication date 28 Jan 2015
• Publisher Springer-Verlag New York Inc.
• Publication City/Country New York, United States
• Language English
• Edition Statement 2013 ed.
• Illustrations note 10 Tables, black and white; XVI, 240 p.
• ISBN10 1489995986
• ISBN13 9781489995988

Download Sequential Experimentation in Clinical Trials : Design and Analysis (9781489995988).pdf, available at ebookdownloadfree.co for free.

GET FREE NOW